Due to the infrequent presentation of this entity, the publication of this case is considered of scientific value. Symptoms and diagnosis of phyllodes tumors of the breast. A single slide showed convincing osteosarcomatous and chondrosarcomatous heterologous differentiation in the stroma, which was overlooked in the original pathology report. They are classified into benign, borderline or malignant based on histologic factors. Jan 22, 2020 the most common symptom of a phyllodes tumor is a painless breast lump that you or your doctor can feel while examining the breasts.
Phyllodes tumors of the breast are rare tumors that start in the connective stromal tissue of the breast. We present a case of a 33yearold woman affected by. Malignant phyllodes tumor of the breast accounts for up to a quarter of the phyllodes tumors. Malignant phyllodes tumor cystosarcoma phyllodes of the breast with lipoblastic.
Phyllodes breast tumor, is a very rare type of neoplasm having a fibroepithelial. If the phyllodes tumor of the breast is benign or borderline histology, radiation therapy not routinely recommended after excision. Differentiation of phyllodes breast tumors from fibroadenomas. Phyllodes tumor is a rare fibroepithelial neoplasm of the breast, with unpredictable. The most common site of phyllodes tumor is the breast in general, phyllodes tumor may be classified as benign, malignant, or borderline tumor based on their behavior. Please use one of the following formats to cite this article in your essay, paper or report. My doctor put both a fiberdinoma and phyllodes tumor down on the table for me because i was 19, diagnosed on sept 2012. Phyllodes tumor is an extremely rare tumor of the breast. Malignant phyllodes tumor is a rare and aggressive fibroepithelial neoplasm. A final diagnosis of metastatic phyllodes tumor to the bowel was then rendered. Nov 15, 2019 borderline phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. Longterm outcomes of malignant phyllodes tumors patients. Jul 04, 2016 surgery is the main treatment for phyllodes tumors of the breast. The vast majority of phyllodes tumors occur in women, with a median age of presentation of 42 to 45 years range 10 to 82 years 3,68.
Who classifies tumors into benign, borderline and malignant and it is the best methods to predict the local recurrence, distant metastasis or bath after resection. Phyllodes tumors fillodes or fullohdeez can also be spelled phylloides tumors fulloydeez. It occurs in females in the third and fourth decades. For language access assistance, contact the ncats public information officer. The clinical presentation of this tumor is unilateral, and the behavior and. The preoperative diagnosis and proper management are crucial in phyllodes tumor because of their tendency to recur and malignant potential in some of these tumors. Generally, phyllodes tumor presents as a rapidly growing and clinically benign breast lump in females within the fourth or fifth decade of life. They are graded as benign, borderline or malignant based on the world health organisation who classification, according to a constellation. Phyllodes tumors of the breast american cancer society. They get their name from the leaflike pattern in which they grow phyllodes means leaflike in greek.
A total of 41% were benign phyllodes tumors, 41% were borderline and 18%. Phyllodes tumors are most common in women in their 40s, but women of any age can have them. Listing a study does not mean it has been evaluated by the u. The term cystosarcoma phyllodes was coined by johannes muller in 1838 to describe the gross appearance of this cystic, fleshy, leafy, tumor of the breast, which he clearly stated to be a benign tumor. Apr 29, 2011 phyllodes tumors are uncommon and unpredictable. The definitive diagnosis of these fibroepithelial tumors is histologic. Phyllodes tumors grow in the connective tissue of the breast, called the stroma. If the phyllodes tumor of the breast is benign or borderline histology, radiation therapy not. Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. Because of the scarcity of the disease, there are no evidencebased treatment or followup guidelines established.
Nov 05, 2018 malignant phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. Malignant phyllodes tumor mpt is a rare breast malignancy. If you have problems viewing pdf files, download the latest version of adobe reader. Malignant phyllodes tumor cystosarcoma phyllodes of the breast with lipoblastic differentiation. Diagnosing phyllodes tumors usually involves a combination of steps, such as a physical exam, a mammogram, and a biopsy.
In men, phyllodes tumors usually occur in association with gynecomastia 3. Phyllodes tumor of the breast is a rare tumor, which is part of fibroepithelial breast tumors with a wide range of clinical presentation and biological behavior. Those phyllodes tumors grouped a set of pathologies characterized by presenting an architecture histological stromal and epithelial. Phyllodes is greek for leaflike, the phyllodes tumor grows in a leaflike pattern within the connective tissue of the breast. Mar 20, 20 depending on the size of the breast and the location of the phyllodes tumor, mastectomy may also be required for tumors that are between 5 and 10 cm in diameter. Stromal component negative for high molecular weight keratin and p63.
Biopsy of the tumor was performed and showed a sarcomatous proliferation consistent with metastatic malignant phyllodes tumor. No single feature is reliable to predict clinical behavior of phyllodes tumors. These are rare breast tumors that start in the connective stromal tissue of the breast. A phyllodes tumor of the breast is a rare fibroepithelial tumor, accounting for 0. Radiation therapy after surgery in treating women with. A tumor is an abnormal mass of tissue that may be benign, premalignant, or cancerous. Traditional histological classification as benign, borderline or malignant. These cases have been published under a variety of diagnoses, including phyllodes tumor and prostatic stromal proliferation of uncertain malignant potential as well as a malignant tumor called prostatic stromal sarcoma. Malignant phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women.
Malignant phyllodes tumor radiology reference article. The phyllodes breast tumor is a special kind of fibroadenoma that constitutes 0. Phyllodes tumors johns hopkins kimmel cancer center. The term phyllodes tumor, which was previously known as cystosarcoma phyllodes, refers to a group of lesions with varying metastatic potential. Common symptoms reported by people with phyllodes tumor. Phyllodes tumors are uncommon and unpredictable mayo clinic. In their least aggressive form, phyllodes tumors behave like benign fibroadenomas, although with a propensity to recur locally following excision without wide margins. Phyllodes tumor of breast could be either benign or malignant variety and they can grow into very large sizes and distort the breast. It doesnt hurt to get a second look becuase regardless if its benign or melignant it seems like its just the same procedures done. The patient received the same chemotherapy regimen as in the first case but without any response on her imaging follow up after 6 months.
It is generally considered a non cancerous tumor, but in rare cases may be malignant. Phyllodes tumor is a rare fibroepithelial neoplasm of the breast, with unpredictable clinical behavior. Radiation oncologybreastphyllodes wikibooks, open books. Phyllodes tumours are rare and are usually benign not cancer. Breast reconstruction was performed using a skin graft. In contrast to other fibroadenomas, the phyllodes breast tumor has the potential to grow to a large size. Focal fibroadenomatous and fibrocystic changes are observed. Lymph node involvement is rarely described in phyllodes tumors. This includes the tissue and ligaments that surround the ducts. This is the case regardless of whether they are benign or malignant. This study evaluated the survival of mpt patients to create recommendations for management. Phyllodes tumor of the breast genetic and rare diseases. Feb 27, 2019 please use one of the following formats to cite this article in your essay, paper or report. They are graded as benign, borderline or malignant based on the world health organisation who classification, according to a constellation of 5.
Because these tumors can come back if enough normal tissue is not removed, surgery should involve removing the tumor and at least 1 cm of the surrounding tissue. Despite its classification into benign, borderline and malignant, their behavior tends to be uncertain. The tumor is rarely found in adolescents and the elderly. Abstract phyllodes tumors is a rare fibroepithelial neoplasm. They account for less than 1% of all breast neoplasms. It is typically a large, fast growing mass that forms from the periductal stroma of the breast. Phyllodes tumor, also known as cystosarcoma phyllodes, is a rare fibroepithelial tumor of the breast which has some resemblance to a fibroadenoma. Phyllodes tumors is a rare fibroepithelial neoplasm.
Learn more about the symptoms and diagnosis of phyllodes tumors. The most common symptom of a phyllodes tumor is a painless breast lump that you or your doctor can feel while examining the breasts. This is why surgery to remove a phyllodes tumor is recommended, even if it is thought to be benign. En realidad, otro autor lo habia descrito en 1828 pero no tuvo trascendencia su descripcion. Although uncommon, these tumors can metastasize to other organs. Phyllodes tumours pts of the breast are uncommon fibroepithelial neoplasms, comprising 0. Phyllodes tumors are rare solid lumps that usually present as a mass found during a womans breast selfexamination or on a routine physical examination. Phyllodes tumor of the breast is a biphasic fibroepithelial neoplasm. Phyllodes tumor of the breast is a rare neoplasm, representing less than 1% of all breast tumors.
The word phyllodes derives from the greek word for leaf and is used because the tumor has a leaflike, lobulated appearance when sectioned. Phyllodes tumors appear very similar to a benign lump known as a fibroadenoma. Jan 19, 20 phyllodes tumor bears specific clinical characteristic and can be considered as a differential diagnosis for the breast lumps. Phyllodes tumor of the breast is a rare tumor, which is part of fibroepithelial. Phyllodes tumors are rare fibroepithelial breast tumors, which are sometimes difficult to preoperative diagnoses and have unpredictable clinical outcome. Macrophages are frequently found in close proximity with 4 myofibroblasts, but it is uncertain whether they are involved in the myo. Distant metastases in phyllodes tumours of the breast. They usually occur in middleaged to elderly women but can occur at any age. Surgical management of phyllodes tumors oncology jama.
Request pdf tumor phyllodes phyllodes tumors is a rare fibroepithelial neoplasm. Cystic epithelialstromal tumors of the prostate are rare, with 82 cases reported in literature. A 40 yearold white woman presented with threeweek history of pain and functional impairment of the left lower limb. Aggressive malignant phyllodes tumor sciencedirect. Treatment and surgery for phyllodes tumors news medical. Ki67 labeling index revealed positivity in about 10% of stromal cells, thus the case is consistent with phyllodes tumor. Only a few cases of malignant phyllodes tumors metastatic to bone have been reported. Treatment is surgical with wide excision and diseasefree margins. Jan 27, 2003 radiation therapy after surgery in treating women with phyllodes tumor of the breast the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Welcome to cancer chat mcvikki although im sorry for the reason youve joined us.
Phyllodes tumor breast imaging center highland hospital. Spindled component may be positive for high molecular weight keratin or p63. Pdf phyllodes tumor represents one of the fibroepithelial breast. Pathology it is generally thought that it is the stromal component t. My oncologist said its up to me if i want radiation, since its only recently being used more frequently for this type of cancer. Phyllodes tumors are uncommon fibroepithelial breast tumors that are capable of a diverse range of biologic behaviors. However, some phyllodes tumours are malignant cancer. The most common site of phyllodes tumor is the breast in general, phyllodes tumor may be classified as benign, malignant, or borderline tumor based on. The phyllodes tumor pt of the breast is a rare disease of unknown origin. While managing a giant phyllodes tumor, emphasis should be on complete extirpation of all visible tumors and breast tissue during mastectomy to minimize the chances of recurrence. Tumor filodes maligno cistosarcoma filodes mamario con. Highergrade tumors are more common in older patients 9. Phyllodes tumor bears specic clinical characteristic and can be considered as a di erential diagnosis for the breast lumps.
Find out more about the types of tumor and the outlook for people with each type. A 30yearold woman presented with a 1year history of a palpable, asymptomatic right breast mass without axillary lymphadenopathy and family history of breast carcinoma. Differential diagnosis phyllodes tumor of the breast. Retrospectively, we examined the clinicopathologic features of 27 breast cancer patients treated for malignant phyllodes tumors from 1995 to 2004 and analyzed their recurrence and survival outcomes using contingency tables, a logistic regression model, or a proportional hazard model. Twentyfive axillary lymph nodes and surgical margins were all negative for tumor. Hypothesis although phyllodes tumors have minimal metastatic potential, we hypothesized that they have a proclivity for local recurrence and should be excised with a wide margin. May 11, 2017 a phyllodes tumor is a rare tumor of the breast. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Phyllodes tumor of the breast is a rare neoplasm, representing less than 1% of all breast. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Once i got surgery it came back as a phyllodes tumor that was benign. Unlike other kinds of benign breast lesions, benign phyllodes tumors can grow very quickly and become very large. Please, refer to the main article on phyllodes tumors for a general discussion.
No evidence of tumor necrosis, cytologic atypia, invasive margin, heteroglous elements. They are most common in women in their 30s and 40s, although women of. Malignant phyllodes tumors are a form of breast cancer. To describe the management of the ft in breast pathology unit. Phyllodes tumors are rare fibroepithelial neoplasms that account for 0. Bone metastasis from malignant phyllodes breast tumor. Phyllodes tumor page 1 of 4 md anderson cancer center.
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